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The boats and colorful buildings of Santa Margherita Ligure. Set on the Gulf of Tigullio between Rapallo and Portofino, the resort/fishing town of Santa Margherita Ligure really couldn’t be in a better neighborhood. Fashionable but much quieter than Portofino next door, life in Santa Margherita Ligure centers around the lovely palm-laden harbor, where boating and simple sunning are the orders of the day. The town has some good shopping options, lovely cafes and interesting sights like its 16th-century castle and the 17th-century Basilica di Santa Margherita. This is part of the Italian Riviera